Incidence and severity of myofiber branching with regeneration and aging

Skeletal Muscle

Table 1 Summary data of myofiber branching in mdx , myotoxin-injured and aged wild-type mouse gastrocnemius muscles

	Young mdx(5.5 to 8 wk)	Adult mdx(30 to 31 wk)	Myotoxin-injured WT^a(2 to 6 mo)	Aged WT^a(20 to 21 mo)
Regenerated myofibers/total myofibers^b	38.6 ± 15.3	100 ± 0	69.2 ± 5.0	0
Branched myofibers/total myofibers^b	34.7 ± 10.3	97.1 ± 2.3	38.2 ± 1.3	6.5 ± 0.6
Branched myofibers/regenerated myofibers^b	85.8 ± 5.8	97.1 ± 2.3	55.4 ± 3.6	0
Number of branches per branched myofiber^c	1.7 ± 0.3	4.0 ± 0.5	1.6 ± 0.1	1.0 ± 0

^aWT, Wild type. ^bData are mean (%) ± SEM (n = 3 to 6 mice). ^cData are mean ± SEM (n = 3 to 6 mice).

ISSN: 2044-5040