Figure 1

Representative images of transverse cryosections of regenerated muscles that had been grafted with CD133+ cells. Sections were stained with human lamin A/C and human spectrin antibodies (both green), and nuclei were counterstained with DAPI (blue). (a), (b) and (c) are sections from Rag2-/γ chain-/C5- mice, and (d), (e) and (f) are sections from mdx nude mice. (a) and (d) were modulated prior to cell transplantation with irradiation only, (b) and (e) were modulated by cryodamage only, (c) and (f) were modulated with irradiation+cryodamage. Scale bar = 50 μm. Rag, recombinase-activating gene.