Figure 5
From: In vitro stability of therapeutically relevant, internally truncated dystrophins
Melt curves obtained by differential scanning fluorimetry. Differential scanning fluorimetry (DSF) melt curves for exon-skipped dystrophins (A), gene therapy dystrophins (B), and utrophins (C). Fluorescence was monitored at 610 nm from 20°C to 90°C, and normalized from 0 to 1 fraction unfolded and a representative curve plotted. See Table 1 for melting temperatures (DSF Tm). hDys - human dystrophin, hUtr - human utrophin.