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Table 2 Transcripts modulated in A/J vs. WT myoblasts co-cultured with M1 macrophages

From: Upregulated IL-1β in dysferlin-deficient muscle attenuates regeneration by blunting the response to pro-inflammatory macrophages

Gene symbol

Description

WT-M1 vs. WT

AJ vs. WT

AJ-M1 vs. AJ

Ifi27

Interferon, alpha-inducible protein 27

16.32

2.41

17.75

Ifit3

Interferon-induced protein with tetratricopeptide repeats 3

10.49

1.75

3.44

C2

Complement component 2

2.88

2.63

n/a

Ifitm1

Interferon-induced transmembrane protein 1

2.86

1.76

n/a

MMP2

Matrix metallopeptidase 2

2.77

2.54

n/a

IL7

Interleukin 7

2.62

1.69

n/a

H2-T23

Histocompatibility 2, T region locus 23

2.56

4.41

n/a

Ifitm3

Interferon-induced transmembrane protein 3

2.50

1.65

n/a

Vdr

Vitamin D (1,25-dihydroxyvitamine D3) receptor

2.37

2.18

n/a

Tnfaip2

Tumor necrosis factor, alpha-induced protein 2

2.28

1.57

n/a

Csf1

Colony stimulating factor 1

2.25

1.81

n/a

CCL9

Chemokine (C-C motif) ligand 9

2.23

1.99

2.79

Ltbp1

Latent transforming growth factor beta binding protein 1

2.20

1.53

n/a

Pde4b

Phosphodiesterase 4B, cAMP-specific

2.14

1.61

1.73

H2-Q5

Histocompatibility 2, Q region locus 5

2.00

2.63

n/a

Slc1a3

Solute carrier family 1 (glial high affinity glutamate transporter), member 3

1.99

5.59

n/a

Angptl4

Angiopoietin-like 4

1.98

1.93

n/a

Gch1

GTP cyclohydrolase 1

1.94

2.48

3.14

Bdnf

Brain-derived neurotrophic factor

1.93

1.54

n/a

P2rx4

Purinergic receptor P2X, ligand-gated ion channel 4

1.86

1.82

n/a

Tgif1

TGFB-induced factor homeobox 1

1.82

2.38

n/a

Serpinh1

Serpin peptidase inhibitor, clade H (heat shock protein 47)

1.76

1.53

1.64

Stat1

Signal transducer and activator of transcription 1

1.67

1.77

−1.72

Ccnd1

Cyclin D1

1.64

1.57

1.66

Dab2

Disabled 2, mitogen-responsive phosphoprotein

1.62

1.79

n/a

Nfkbie

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

1.60

n/a

1.54

Tlr2

Toll-like receptor 2

1.58

1.75

n/a

Bmpr2

Bone morphogenetic protein receptor, type II

1.50

1.58

n/a

Actn3

Actinin, alpha 3

−1.50

−1.50

n/a

Tlr4

Toll-like receptor 4

−1.53

n/a

−1.56

Rgs16

Regulator of G-protein signaling 16

−1.54

−1.64

n/a

Dpp3

Dipeptidyl-peptidase 3

−1.56

−1.63

n/a

Myh7

Myosin, heavy chain 7 (type I)

−1.65

−1.87

n/a

Id1

Inhibitor of DNA binding 1

−1.72

−1.53

−1.59

IL1b

Interleukin 1 beta

−1.73

3.05

−2.89

Cdkn1c

Cyclin-dependent kinase inhibitor 1C (p57, kip2)

−1.75

−18.10

2.61

Mef2c

Myocyte enhancer factor 2C

−1.80

−1.86

−2.27

Btrc

Beta-transducin repeat containing E3 ubiquitin protein ligase

−1.89

−1.50

n/a

Igf1

Insulin-like growth factor 1

−1.91

−1.71

n/a

Tgfb1

Transforming growth factor, beta 1

−1.96

1.58

−2.56

Tgfb2

Transforming growth factor, beta 1

−2.00

n/a

−1.84

Musk

Muscle, skeletal, receptor tyrosine kinase

−2.03

−4.73

−1.90

Myoz2

Myozenin 2

−2.88

−1.68

n/a

Sgcg

Sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)

−3.01

−1.83

−1.72

Myl3

Myosin, light chain 3, skeletal slow

−3.07

−2.42

−1.53

Myf6

Myogenic factor 6

−4.13

−3.53

−1.94

Myh1

Myosin, heavy chain 1 (type IIx/d)

−5.89

1.91

n/a

  1. Fold-change values of Illumina Gene array transcript subset which showed significant modulation by WT-M1 co-culture vs. WT alone compared to their fold-change values in A/J vs. WT and A/J-M1 co-culture vs. A/J alone. Only transcripts with fold-change values >1.5 and P values <0.01 were considered for analysis. ANOVA was applied to verify significance