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Table 2 Transcripts modulated in A/J vs. WT myoblasts co-cultured with M1 macrophages

From: Upregulated IL-1β in dysferlin-deficient muscle attenuates regeneration by blunting the response to pro-inflammatory macrophages

Gene symbol Description WT-M1 vs. WT AJ vs. WT AJ-M1 vs. AJ
Ifi27 Interferon, alpha-inducible protein 27 16.32 2.41 17.75
Ifit3 Interferon-induced protein with tetratricopeptide repeats 3 10.49 1.75 3.44
C2 Complement component 2 2.88 2.63 n/a
Ifitm1 Interferon-induced transmembrane protein 1 2.86 1.76 n/a
MMP2 Matrix metallopeptidase 2 2.77 2.54 n/a
IL7 Interleukin 7 2.62 1.69 n/a
H2-T23 Histocompatibility 2, T region locus 23 2.56 4.41 n/a
Ifitm3 Interferon-induced transmembrane protein 3 2.50 1.65 n/a
Vdr Vitamin D (1,25-dihydroxyvitamine D3) receptor 2.37 2.18 n/a
Tnfaip2 Tumor necrosis factor, alpha-induced protein 2 2.28 1.57 n/a
Csf1 Colony stimulating factor 1 2.25 1.81 n/a
CCL9 Chemokine (C-C motif) ligand 9 2.23 1.99 2.79
Ltbp1 Latent transforming growth factor beta binding protein 1 2.20 1.53 n/a
Pde4b Phosphodiesterase 4B, cAMP-specific 2.14 1.61 1.73
H2-Q5 Histocompatibility 2, Q region locus 5 2.00 2.63 n/a
Slc1a3 Solute carrier family 1 (glial high affinity glutamate transporter), member 3 1.99 5.59 n/a
Angptl4 Angiopoietin-like 4 1.98 1.93 n/a
Gch1 GTP cyclohydrolase 1 1.94 2.48 3.14
Bdnf Brain-derived neurotrophic factor 1.93 1.54 n/a
P2rx4 Purinergic receptor P2X, ligand-gated ion channel 4 1.86 1.82 n/a
Tgif1 TGFB-induced factor homeobox 1 1.82 2.38 n/a
Serpinh1 Serpin peptidase inhibitor, clade H (heat shock protein 47) 1.76 1.53 1.64
Stat1 Signal transducer and activator of transcription 1 1.67 1.77 −1.72
Ccnd1 Cyclin D1 1.64 1.57 1.66
Dab2 Disabled 2, mitogen-responsive phosphoprotein 1.62 1.79 n/a
Nfkbie Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 1.60 n/a 1.54
Tlr2 Toll-like receptor 2 1.58 1.75 n/a
Bmpr2 Bone morphogenetic protein receptor, type II 1.50 1.58 n/a
Actn3 Actinin, alpha 3 −1.50 −1.50 n/a
Tlr4 Toll-like receptor 4 −1.53 n/a −1.56
Rgs16 Regulator of G-protein signaling 16 −1.54 −1.64 n/a
Dpp3 Dipeptidyl-peptidase 3 −1.56 −1.63 n/a
Myh7 Myosin, heavy chain 7 (type I) −1.65 −1.87 n/a
Id1 Inhibitor of DNA binding 1 −1.72 −1.53 −1.59
IL1b Interleukin 1 beta −1.73 3.05 −2.89
Cdkn1c Cyclin-dependent kinase inhibitor 1C (p57, kip2) −1.75 −18.10 2.61
Mef2c Myocyte enhancer factor 2C −1.80 −1.86 −2.27
Btrc Beta-transducin repeat containing E3 ubiquitin protein ligase −1.89 −1.50 n/a
Igf1 Insulin-like growth factor 1 −1.91 −1.71 n/a
Tgfb1 Transforming growth factor, beta 1 −1.96 1.58 −2.56
Tgfb2 Transforming growth factor, beta 1 −2.00 n/a −1.84
Musk Muscle, skeletal, receptor tyrosine kinase −2.03 −4.73 −1.90
Myoz2 Myozenin 2 −2.88 −1.68 n/a
Sgcg Sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) −3.01 −1.83 −1.72
Myl3 Myosin, light chain 3, skeletal slow −3.07 −2.42 −1.53
Myf6 Myogenic factor 6 −4.13 −3.53 −1.94
Myh1 Myosin, heavy chain 1 (type IIx/d) −5.89 1.91 n/a
  1. Fold-change values of Illumina Gene array transcript subset which showed significant modulation by WT-M1 co-culture vs. WT alone compared to their fold-change values in A/J vs. WT and A/J-M1 co-culture vs. A/J alone. Only transcripts with fold-change values >1.5 and P values <0.01 were considered for analysis. ANOVA was applied to verify significance