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Table 3 Transcripts modulated in A/J vs. WT myoblasts co-cultured with M2a macrophages

From: Upregulated IL-1β in dysferlin-deficient muscle attenuates regeneration by blunting the response to pro-inflammatory macrophages

Gene symbol Description WT-M2 vs. WT AJ vs. WT AJ-M2 vs. AJ
Myl2 Myosin, light polypeptide 2, regulatory, slow 2.31 n/a 3.07
Sdc4 Syndecan 4 2.04 −2.16 n/a
Nrap Nebulin-related anchoring protein 1.98 n/a 2.29
Calr Calreticulin 1.88 n/a −1.87
Mylk2 Myosin light chain kinase 2 1.88 n/a n/a
Ltbp1 Latent transforming growth factor beta binding protein 1 1.85 1.54 n/a
Ckm Creatine kinase, muscle 1.83 n/a 1.78
Mybpc2 Myosin binding protein C, fast type 1.64 2.47 1.94
Rhob Ras homolog family member B 1.62 n/a 1.58
Myh7 Myosin, heavy chain 7 (type I) 1.61 −1.87 n/a
Il4 Interleukin 4 1.59 n/a n/a
Ryr1 Ryanodine receptor 1 1.57 n/a n/a
Myoz2 Myozenin 2 1.56 −1.69 1.81
Myh6 Myosin, heavy chain 7 (cardiac) 1.52 n/a 2.00
Myom1 Myomesin 1 1.52 n/a 1.54
Id2 Inhibitor of DNA binding 2 −1.56 1.77 −2.20
Il7 Interleukin 7 −1.57 1.70 n/a
Rab27b RAB27B, member RAS oncogene family −1.61 n/a −1.67
Iigp2 Interferon inducible GTPase 2 −1.79 2.06 −2.83
Psmb8 Proteosome subunit, beta type 8 −1.84 1.78 −1.86
Ifi47 Interferon gamma inducible protein 47 −1.90 2.18 −2.00
C2 Complement 2 −1.95 2.64 −2.40
Casp1 Caspase 1 −2.18 1.98 −2.22
Plk1 Polo-like kinase 1 −2.29 −2.76 −1.68
Irf1 Interferon regulatory factor 1 −2.91 1.88 −2.43
Gbp2 Guanylate binding protein 2, interferon-inducible −3.37 1.60 −2.33
Akt2 v-akt murine thymoma viral oncogene 2 n/a n/a 1.51
Gsk3B Glycogen synthase kinase 3 n/a n/a −1.75
Itgb1 Integrin, beta 1 (fibronectin receptor beta) n/a n/a −2.37
Jak1 Janus kinase 1 n/a n/a −1.87
Myoz1 Myozenin 1 n/a n/a 1.70
Ripk1 Receptor (TNFRSF)-interacting serine-threonine kinase 1 n/a n/a −1.51
Vegfc Vascular endothelial growth factor C n/a n/a −1.50
Slc1a3 Solute carrier family 1 (glial high affinity glutamate transporter), member 3 n/a 5.59 −1.98
H2-T23 Histocompatibility 2, T region locus 23 n/a 4.41 −1.66
Il1b Interleukin 1 beta n/a 3.05 −2.47
Cxcl16 Chemokine (C-X-C motif) ligand 16 n/a 2.92 −1.74
Col5a2 Collagen, type V, alpha 2 n/a 2.66 −1.72
Crlf1 Cytokine receptor-like factor 1 n/a 2.64 −1.69
Ccl9 Chemokine (C-C motif) ligand 9 n/a 2.00 1.50
Angptl4 Angiopoietin-like 4 n/a 1.93 −1.52
Stat1 Signal transducer and activator of transcription 1 n/a 1.77 −1.61
Tnfrsf1b Tumor necrosis factor receptor superfamily, member 1b n/a 1.63 −1.51
Bmpr2 Bone morphogenetic protein receptor 2 n/a 1.58 −1.61
Stam2 Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 n/a 1.57 −1.62
Gvin1 GTPase, very large interferon inducible 1 n/a 1.53 −1.75
Tnfsf9 Tumor necrosis factor (ligand) superfamily, member 9 n/a 1.51 −1.57
Prkaca Protein kinase, cAMP-dependent, catalytic, alpha n/a −1.58 1.51
Prosapip1 ProSAPiP1 protein n/a −1.90 1.67
Myf6 Myogenic factor 6 n/a −3.54 2.62
Musk Muscle, skeletal, receptor tyrosine kinase n/a −4.73 −1.53
Cdkn1c Cyclin-dependent kinase inhibitor 1C (p57, Kip2) n/a −18.11 5.52
  1. Fold-change values of Illumina Gene array transcript subset which showed significant modulation by WT-M2a co-culture vs. WT alone compared to their fold-change values in A/J vs. WT and A/J-M2a co-culture vs. A/J alone. Only transcripts with fold-change values >1.5 and P values <0.01 were considered for analysis. ANOVA was applied to verify significance