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Table 1 Parameters of fitted I-V and [ΔF/F]-V curves

From: Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit

  I-V data   [∆F/F]-V data
  G max (nS/nF) k (mV) V half (mV) Vrev (mV) (∆F/F)max k (mV) V half (mV)
WT RyR1 (n = 12) 264 ± 16 5.4 ± 0.4 10.5 ± 1.8 71 ± 1.8 3.4 ± 0.7 3.9 ± 0.5 -4.7 ± 1.6
RyR1 K-Q (n = 10) 201 ± 17* 5.7 ± 0.3 11.5 ± 1.7 70 ± 2.1 1.6 ± 0.3* 4.1 ± 04. -2.5 ± 1.7
  1. Maximal L-channel conductance (G max), the potential for half-maximal G max (V half), slope factor (k), and reversal potential (V rev). Values presented as mean ± SEM for I-V data presented in Fig. 6c. Maximal Ca2+ transient [(ΔF/F)max], the potential at half maximal fluorescence (V half) and slope factor (k). Values presented as mean ± SE for [ΔF/F]-V data presented in Fig. 6d
  2. *p < 0.05 vs WT RyR1-expressing dyspedic myotubes