Table 3 Gene set enrichment analysis for the 484 genes upregulated with age and the 473 downregulated

KEGG_COMPLEMENT_AND_COAGULATION_CASCADES

0.80

2.32

0.0047

REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT

0.89

2.18

0.0133

REACTOME_COMPLEMENT_CASCADE

0.89

2.15

0.0138

BIOCARTA_COMP_PATHWAY

0.86

2.21

0.0148

KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS

0.75

2.07

0.0288

BIOCARTA_CLASSIC_PATHWAY

0.90

2.04

0.0361

Downregulated sets

REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT

−0.76

−2.90

0.0000

MITOCHONDRION

−0.59

−2.70

0.0000

REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE

−0.81

−2.48

0.0008

MITOCHONDRIAL_ENVELOPE

−0.74

−2.39

0.0010

MITOCHONDRIAL_MEMBRANE

−0.74

−2.37

0.0011

MITOCHONDRIAL_PART

−0.74

−2.39

0.0012

KEGG_PARKINSONS_DISEASE

−0.73

−2.40

0.0013

ORGANELLE_INNER_MEMBRANE

−0.74

−2.30

0.0014

ORGANELLE_ENVELOPE

−0.68

−2.33

0.0015

MITOCHONDRIAL_INNER_MEMBRANE

−0.74

−2.30

0.0015

ENVELOPE

−0.68

−2.26

0.0019

KEGG_OXIDATIVE_PHOSPHORYLATION

−0.64

−2.23

0.0024

REACTOME_PYRUVATE_METABOLISM

−0.81

−2.22

0.0025

COFACTOR_METABOLIC_PROCESS

−0.69

−2.19

0.0037

KEGG_ALZHEIMERS_DISEASE

−0.60

−2.07

0.0117

MITOCHONDRIAL_MEMBRANE_PART

−0.74

−2.08

0.0123

REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_

−0.70

−2.02

0.0161

REACTOME_GLUCOSE_METABOLISM

−0.70

−2.03

0.0162

REACTOME_GLUCONEOGENESIS

−0.77

−2.01

0.0187

ION_TRANSPORT

−0.82

−1.99

0.0199

COENZYME_METABOLIC_PROCESS

−0.82

−2.00

0.0200

REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX

−0.81

−1.96

0.0246

HYDROGEN_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY

−0.78

−1.94

0.0283

INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY

−0.78

−1.91

0.0340

ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY

−0.50

−1.90

0.0378

MONOVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY

−0.78

−1.89

0.0380

KEGG_CITRATE_CYCLE_TCA_CYCLE

−0.77

−1.89

0.0385