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Table 3 Gene set enrichment analysis for the 484 genes upregulated with age and the 473 downregulated

From: A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging

Upregulated sets ES NES FDR q value
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 0.80 2.32 0.0047
REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT 0.89 2.18 0.0133
REACTOME_COMPLEMENT_CASCADE 0.89 2.15 0.0138
BIOCARTA_COMP_PATHWAY 0.86 2.21 0.0148
KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 0.75 2.07 0.0288
BIOCARTA_CLASSIC_PATHWAY 0.90 2.04 0.0361
Downregulated sets    
REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT −0.76 −2.90 0.0000
MITOCHONDRION −0.59 −2.70 0.0000
REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE −0.81 −2.48 0.0008
MITOCHONDRIAL_ENVELOPE −0.74 −2.39 0.0010
MITOCHONDRIAL_MEMBRANE −0.74 −2.37 0.0011
MITOCHONDRIAL_PART −0.74 −2.39 0.0012
KEGG_PARKINSONS_DISEASE −0.73 −2.40 0.0013
ORGANELLE_INNER_MEMBRANE −0.74 −2.30 0.0014
ORGANELLE_ENVELOPE −0.68 −2.33 0.0015
MITOCHONDRIAL_INNER_MEMBRANE −0.74 −2.30 0.0015
ENVELOPE −0.68 −2.26 0.0019
KEGG_OXIDATIVE_PHOSPHORYLATION −0.64 −2.23 0.0024
REACTOME_PYRUVATE_METABOLISM −0.81 −2.22 0.0025
COFACTOR_METABOLIC_PROCESS −0.69 −2.19 0.0037
KEGG_ALZHEIMERS_DISEASE −0.60 −2.07 0.0117
MITOCHONDRIAL_MEMBRANE_PART −0.74 −2.08 0.0123
REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ −0.70 −2.02 0.0161
REACTOME_GLUCOSE_METABOLISM −0.70 −2.03 0.0162
REACTOME_GLUCONEOGENESIS −0.77 −2.01 0.0187
ION_TRANSPORT −0.82 −1.99 0.0199
COENZYME_METABOLIC_PROCESS −0.82 −2.00 0.0200
REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX −0.81 −1.96 0.0246
HYDROGEN_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY −0.78 −1.94 0.0283
INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY −0.78 −1.91 0.0340
ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY −0.50 −1.90 0.0378
MONOVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY −0.78 −1.89 0.0380
KEGG_CITRATE_CYCLE_TCA_CYCLE −0.77 −1.89 0.0385