Fig. 6

Effects of REGN1033 on muscle atrophy induced by hindlimb unloading. a TA and GA muscle mass after treatment with REGN1033 or an isotype control antibody during 7 days of hindlimb unloading (HLS). One group of mice served as control to the HLS group and received injections with the isotype control antibody. Weights were normalized according to starting body weight, and data are expressed as percent change from normalized non-hindlimb suspended control group. Significance was calculated over normalized non-hindlimb suspended isotype control group (asterisk) or over normalized hindlimb suspended isotype control group (number sign). b Muscle weights at the end of 7 days of hindlimb unloading (HLS) or 7 days of HLS plus 7 days of recovery (HLS + rec). Groups of mice were dosed with isotype control or REGN1033 (10 mg/kg) during the 7-day recovery period. Changes in muscle weights are depicted as the difference in muscle weights compared to the no-hindlimb-suspended group. Statistical significance was calculated vs. animals that were not-hindlimb-suspended (no HLS) or against animals that were hindlimb-suspended for 7 days (7-day HLS). All groups had four to six animals. Data are means ± SEM. *P < 0.05, **P < 0.01, ****P < 0.0001 and ^## P < 0.01, ^### P < 0.001, ^#### P < 0.0001