Fig. 6
From: Pax3-induced expansion enables the genetic correction of dystrophic satellite cells
Contractile function and response to reinjury by muscles engrafted with μDYS-Pax3-induced cells. a Representative examples of maximum isometric tetanic force in TA muscles that had been injected with PBS (contra-lateral leg, gray line) or Pax3 induced (red line). b, c μDYS-Pax3-induced cell transplantation produced a significant improvement in absolute (F 0, b) and specific (sF 0 = F 0 normalized to CSA, c) forces. Error bars represent s.e.m. from a total of six mice. **P < 0.01. d Immunofluorescence staining for embryonic MHC and μDYS in engrafted TA muscles analyzed 10 days after CTX reinjury indicates the presence of newly formed donor myofibers as denoted by co-expression of human μDYS (red) and eMHC (green) (arrows). Arrowheads show μDYS−/eMHC+ host-derived newly formed myofibers. Alexa-647 was used to detect eMHC. DAPI is shown in blue. Scale bar, 50 μm