Fig. 6From: Dystrophin restoration therapy improves both the reduced excitability and the force drop induced by lengthening contractions in dystrophic mdx skeletal muscleMyofribrillar function, muscle fiber ultrastructure, and optimal muscle length following lengthening contractions in the TA muscle from mdx mice and effect of prior cardiotoxin injection. a Calcium maximally activated force of skinned muscle fibers (myofibrillar function) after nine lengthening contractions. b, c Representative images of electron microscopy from mdx mouse illustrating the absence of morphological alterations following nine lengthening contractions (c) as compared to before lengthening contractions (b). d Force drop following nine lengthening contractions in mdx mice, muscles were stretched to try to obtain a new optimal length (L0). e Force drop following lengthening contractions in the cardiotoxin-treated (freshly regenerated) mdx muscle. C57 mice were also shown. f Maximal force before lengthening contractions (initial) in mdx muscle treated with cardiotoxin. C57 mice were also shown. 0LC before lengthening contractions, 9LC after nine lengthening contractions, 9LC + newL0 muscles were stretched to try to obtain a new optimal length (L0) after nine lengthening contractions, Cardio muscle injected with cardiotoxin 3 weeks before, a significantly different from before lengthening contractions (p < 0.05), b significant difference between strains (p < 0.05), c significantly different from 9LC (p < 0.05), d significantly different from C57 (p < 0.05). n ≥ 20 per group for a; n = 7–10 per group for d–f Back to article page