Fig. 9

Effects of everolimus and CDD866 on phosphorylation of SMAD3 levels. Western blot image (a) and quantified value (b). Differentiated C2C12 cells stimulated with or without myostatin (Mst) were used as a positive control for detection of phosphorylation of SMAD3 levels. The lower, weaker band represents phosphorylated SMAD3. Values are expressed as means ± SEM (n = 5–10); **P < 0.01 versus non-tumor control; ^& P < 0.05, ^&& P < 0.01 versus CT-26 control; ^## P < 0.01 versus CT-26 everolimus