Fig. 5

Suppression of HMOX1 worsens muscle dystrophy. a mdx mice were crossed with HMOX1 heterozygotes. b, c Relative gene expression (b) and protein expression (c) of HMOX1 in the muscle from mdx and mdx hmox ^+/− mice. Quantification is shown on the right in c. d–g Serum creatine kinase levels (d), and % Evans blue extravasation (e), fiber size distribution (f), and % central nuclei (g) in gastrocnemius muscle from mdx versus mdx hmox ^+/− mice. n = 8. *P < 0.05, Student’s t test. Scale bar = 50 μm. Error bars indicate ±SEM