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Fig. 6 | Skeletal Muscle

Fig. 6

From: BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified in screens for compounds that inhibit DUX4 expression in FSHD muscle cells

Fig. 6

Elevated cAMP levels inhibit DUX4 target gene expression. ad Expression of the DUX4 target gene MBD3L2 in MB200 FSHD2 myoblasts (a, c) or myotubes (b, d) treated with the adenylyl cyclase activators NKH 477 or forskolin (ab) or the cAMP analog dbcAMP (cd) at the indicated concentrations. Data are normalized to untreated controls

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