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Table 1 Hits from the epigenetic modifier screen

From: BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified in screens for compounds that inhibit DUX4 expression in FSHD muscle cells

Compound % inhibition of ZSCAN4 reporter % inhibition of Renilla luciferase Mechanism
(+)-JQ1 99 (1 μMa) 27 (1 μMa) BET bromodomain inhibitor
PFI-1 89 (1 μMa) 0 (1 μMa) BET bromodomain inhibitor
SGC-CBP30 75 (1 μMa) 24 (1 μMa) CBP/p300 bromodomain inhibitor
Bromosporine 92 (2 μMa) 9 (2 μMa) Pan-bromodomain inhibitor
  1. aConcentration of compound used in the assay