Table 1 Hits from the epigenetic modifier screen
Compound | % inhibition of ZSCAN4 reporter | % inhibition of Renilla luciferase | Mechanism |
|---|---|---|---|
(+)-JQ1 | 99 (1Â ÎĽMa) | 27 (1Â ÎĽMa) | BET bromodomain inhibitor |
PFI-1 | 89 (1Â ÎĽMa) | 0 (1Â ÎĽMa) | BET bromodomain inhibitor |
SGC-CBP30 | 75 (1Â ÎĽMa) | 24 (1Â ÎĽMa) | CBP/p300 bromodomain inhibitor |
Bromosporine | 92 (2Â ÎĽMa) | 9 (2Â ÎĽMa) | Pan-bromodomain inhibitor |