Table 1 Hits from the epigenetic modifier screen
| Compound | % inhibition of ZSCAN4 reporter | % inhibition of Renilla luciferase | Mechanism |
|---|---|---|---|
| (+)-JQ1 | 99 (1 μMa) | 27 (1 μMa) | BET bromodomain inhibitor |
| PFI-1 | 89 (1 μMa) | 0 (1 μMa) | BET bromodomain inhibitor |
| SGC-CBP30 | 75 (1 μMa) | 24 (1 μMa) | CBP/p300 bromodomain inhibitor |
| Bromosporine | 92 (2 μMa) | 9 (2 μMa) | Pan-bromodomain inhibitor |