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Fig. 3 | Skeletal Muscle

Fig. 3

From: A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys

Fig. 3

Effect of mRK35 on skeletal muscle fiber size in mdx mice. a Fiber area count at the mid-belly of the TA muscle harvested from mdx mice following 4 weeks of treatment with 10 mg/kg mRK35 or vehicle (n = 4 per treatment). b Representative cross-sectional images of the TA from vehicle-treated mice. c Representative cross-sectional images of the TA from mRK35-treated animals. Muscle fibers are stained with wheat germ agglutinin in green and counterstained with DAPI, which stains the nuclei, in blue

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Skeletal Muscle

ISSN: 2044-5040

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