A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys

Table 1 IC₅₀ values derived from the cell-based signaling assays

Myostatin inhibitors	IC₅₀ with ligand
	Myostatin	GDF-11	Activin A	Activin B	Activin AB	BMP9
ActRIIB-Fc	< 1 nM	< 1 nM	< 1 nM	< 1 nM	< 1 nM	< 1 nM
Domagrozumab	< 1 nM	< 1 nM	> 1000 nM	81 nM	> 1000 nM	> 1000 nM
mRK35	< 1 nM	< 1 nM	> 1000 nM	37 mM	> 1000 nM	> 1000 nM

Representative IC₅₀ values for a minimum of two assays. ActRIIB-FC activin receptor IIB-fragment crystallizable, GDF-11 growth differentiation factor-11

ISSN: 2044-5040