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Table 1 IC50 values derived from the cell-based signaling assays

From: A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys

Myostatin inhibitors IC50 with ligand
  Myostatin GDF-11 Activin A Activin B Activin AB BMP9
ActRIIB-Fc < 1 nM < 1 nM < 1 nM < 1 nM < 1 nM < 1 nM
Domagrozumab < 1 nM < 1 nM > 1000 nM 81 nM > 1000 nM > 1000 nM
mRK35 < 1 nM < 1 nM > 1000 nM 37 mM > 1000 nM > 1000 nM
  1. Representative IC50 values for a minimum of two assays. ActRIIB-FC activin receptor IIB-fragment crystallizable, GDF-11 growth differentiation factor-11