Fig. 6
From: Diversification of the muscle proteome through alternative splicing
Alternative splicing in Duchenne muscular dystrophy. a Genomic organization of dystrophin gene locus. b Aberrant alternative splicing results in the formation of “out-of-frame” transcripts that cannot encode for functional dystrophin, causing Duchenne muscular dystrophy (DMD). c However, some of the splicing events also yield “in-frame” transcripts that can encode for partially functional dystrophin, the phenotype of which is called Beckers’ syndrome or Becker muscular dystrophy (BMD)