Table 5 Histological analyses of the diaphragm among groups of P448Lneo− (FKRP) with and without treadmill exercise (FKRP-treadmill) and control (BL6) mice at 6 months of age
Measurement | BL6 control | FKRP | FKRP-treadmill | Significantly different groups (adjusted p values using ANOVA followed by post hoc analysis) | |||
|---|---|---|---|---|---|---|---|
N | Mean ± SD | N | Mean ± SD | N | Mean ± SD | ||
Inflammation (foci/mm2) | 8 | 0.5 ± 0.3 | 8 | 4.0 ± 0.8 | 12 | 8.7 ± 2.8 | BL6 vs FKRP: p < 0.01, BL6 vs FKRP-treadmill: p < 0.0001 FKRP vs FKRP-treadmill: p < 0.0001 |
% fibrosis | 8 | 2.0 ± 0.7 | 8 | 13.7 ± 3.8 | 12 | 13.4 ± 2.2 | BL6 vs FKRP: p < 0.0001, BL6 vs FKRP-treadmill: p < 0.0001 |
% central nucleation | 3 | 2.4 ± 0.4 | 3 | 24.8 ± 2.0 | 3 | 44 ± 9.4 | NP |
Fiber diameter size (μm) | 3 | 24.6 ± 2.6 | 3 | 21.3 ± 1.2 | 3 | 26.7 ± 2.5 | NP |
SD of % central nucleation for each mouse | 3 | 1.6 ± 1.2 | 3 | 4.9 ± 3.3 | 3 | 7.7 ± 2.3 | NP |
SD of fiber size for each mouse | 3 | 4.5 ± 0.8 | 3 | 6.3 ± 0.2 | 3 | 8.1 ± 0.2 | NP |