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Table 5 Histological analyses of the diaphragm among groups of P448Lneo (FKRP) with and without treadmill exercise (FKRP-treadmill) and control (BL6) mice at 6 months of age

From: Skeletal, cardiac, and respiratory muscle function and histopathology in the P448Lneo− mouse model of FKRP-deficient muscular dystrophy

Measurement BL6 control FKRP FKRP-treadmill Significantly different groups (adjusted p values using ANOVA followed by post hoc analysis)
N Mean ± SD N Mean ± SD N Mean ± SD
Inflammation (foci/mm2) 8 0.5 ± 0.3 8 4.0 ± 0.8 12 8.7 ± 2.8 BL6 vs FKRP: p < 0.01,
BL6 vs FKRP-treadmill: p < 0.0001
FKRP vs FKRP-treadmill: p < 0.0001
% fibrosis 8 2.0 ± 0.7 8 13.7 ± 3.8 12 13.4 ± 2.2 BL6 vs FKRP: p < 0.0001,
BL6 vs FKRP-treadmill: p < 0.0001
% central nucleation 3 2.4 ± 0.4 3 24.8 ± 2.0 3 44 ± 9.4 NP
Fiber diameter size (μm) 3 24.6 ± 2.6 3 21.3 ± 1.2 3 26.7 ± 2.5 NP
SD of % central nucleation for each mouse 3 1.6 ± 1.2 3 4.9 ± 3.3 3 7.7 ± 2.3 NP
SD of fiber size for each mouse 3 4.5 ± 0.8 3 6.3 ± 0.2 3 8.1 ± 0.2 NP
  1. Statistical analyss not performed on measures with N = 3. SD standard deviation, NP not performed