Deletion of the microtubule-associated protein 6 (MAP6) results in skeletal muscle dysfunction

Skeletal Muscle

Table 2 Body weight, gastrocnemius muscle volume, and in vivo mechanical performance

	WT	MAP6 KO
Body weight (g)	39.3 ± 2.6	35.1 ± 2.0
Gastrocnemius volume (mm³)	142 ± 3	128 ± 2 *
Maximal specific twitch tension (mN/twitch/mm³)	1.53 ± 0.12	1.19 ± 0.07 *
End exercise twitch tension (% of start exercise value)	24 ± 6	20 ± 7
Total tension produced during the whole 6-min exercise (mN/mm³)	440 ± 70	210 ± 30 *

Gastrocnemius volume was calculated in vivo from MR images acquired at rest on anesthetized animals, and mechanical performance was assessed during the 6-min fatiguing exercise for six WT and seven MAP6 KO male mice. Data are presented as mean ± SEM. The Mann-Whitney tests were performed and significant differences (*p < 0.05) are italicized

ISSN: 2044-5040