Fig. 1
From: Metabolic derangements of skeletal muscle from a murine model of glioma cachexia
Orthotopic glioma murine model exhibiting evident body weight loss and glioma formation. The model was established by implanting three human cell lines into the right lateral ventricles of the mice. HEB, CHG5, and U87 represent normal glial, low-grade glioma, and high-grade glioma cells, respectively. Mice inoculated with HEB cells served as the control group. a Body weights of the mice over the course of the study. b Body weight changes in glioma-bearing mice at day 26 of the study period, relative to their initial weights. c Average daily food consumption per mouse over the course of the study period. d Weights of left and right brains of the mice at day 26 of the study period. e Representative micrographs of HE histology of right brains in glioma-bearing mice, relative to controls. Scale bars, 100 μm. Values that were significantly different from the control group were evaluated using one-way ANOVA. Data are presented as mean ± SD (*P < 0 .05; **P < 0.01; ***P < 0.001)