Fig. 2

Decrease of maximum muscle strength and contractile function in t/t compared to WT. a Po, peak isometric tetanic torque produced in vivo by plantar flexor muscles fixed at optimal leg position. Tetanic torque was evoked by applying supramaximal stimuli to the distal portion of the tibial nerve (0.2 msec duration at 150 Hz for 350 msec). b 1/2RT, half-relaxation time. c dF/dt, peak rate of torque development. d dF/dt, peak rate of torque relaxation. e impulse (integration of torque with time). f Po(t) in t/t and WT. *P < 0.05 and **P < 0.01 n = 13–14 in each group