Fig. 1
From: The ancient sarcomeric myosins found in specialized muscles
a Sarcomeric myosins are hetero-hexameric complexes composed of two heavy chains (blue) that are each bound by two non-identical light chains (essential light chain, red and regulatory light chain, yellow). The myosin heavy chain is distinguished by two functional units, a motor domain that contains the catalytic ATPase site and binds actin and an α-helical coiled-coil rod domain that dimerizes and assembles into biopolar thick filaments. b Within the sarcomere, the myosin heavy chain rod drives assembly of biopolar thick filaments (blue) where the myosin motor domains protrude off the surface to interact with the actin thin filament (gray)