Fig. 3From: RNA-sequencing reveals altered skeletal muscle contraction, E3 ligases, autophagy, apoptosis, and chaperone expression in patients with critical illness myopathyPCA and heat map of DEGs of CIM muscle samples with or without passive loading. a PCA of skeletal muscle samples from passively loaded left and nonloaded right legs of ICU patients with CIM using all genes detected (RPKM log2 transformed and mean centered) b Heat map of 182 DEGs between muscle samples obtained from passive loaded left and nonloaded right leg muscles of critically ill ICU patients with CIM (dependent group t test p < 0.05 and fold difference ≥ 1.5). RPKM of each gene was normalized against the nonloaded control of the same patient and followed by log2 transformationBack to article page