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Table 5 Main characteristics of the patients’ samples depicted Fig. 7

From: Automated image-analysis method for the quantification of fiber morphometry and fiber type population in human skeletal muscle

  

All fibers

Type I fibers

Type II fibers

Gender

Age

BMI (kg/m2)

Mean CSA (μm2)

Atrophy factor

Hypertrophy factor

Atrophy factor

Hypertrophy factor

Atrophy factor

Hypertrophy factor

DM

F

26

NA

1496.6 ± 10.4

5.2

0.002

4.1

0.0004

6.2

0.004

ASM

F

71

NA

1051.4 ± 9.2

9.5

0.004

5.4

0.008

15.0

0.000

NAM

F

62

NA

1938.5 ± 25.1

4.6

0.04

2.8

0.05

7.4

0.02

Neurogenic Atrophy

F

55

17.9

1227.4 ± 8.8

6.5

0.000

4.2

0.000

10.2

0.000

Type II atrophy

M

76

18.3

1782.2 ± 19.5

4.8

0.037

1.1

0.07

8.1

0.002

Hypertrophy

F

60

27.5

4735 ± 35.4

0.3

3.7

0.3

0.6

0.4

7.2

  1. Deltoid muscle samples from dermatomyositis (DM), anti-synthetase myopathy (ASM), necrotizing autoimmune myopathy (NAM), and muscle atrophy patients (neurogenic and type II atrophy), as well as a patient with fiber hypertrophy, were evaluated using our developed macro in Fiji-ImageJ. Values for CSA are means ± SEM. Atrophy and hypertrophy factors for all, type I, and type II myofibers were computed based on a score for the fibers’ CSA size and normalized by the number of each fiber population within a section. CSA cross-sectional area, BMI mody mass index