Fig. 1

Ibuprofen delayed in vitro wound healing. A monolayer of skeletal muscle cells was treated with 0.05 mg/ml, 0.1 mg/ml, 0.2 mg/ml, and 0.4 mg/ml ibuprofen. After 24 h, the cells were scratched to produce a linear, cell-free zone. The cell-free zones were photographed at × 200 and are indicated by the black dotted lines (a). The relative wound healing rate was calculated as the ratio of the remaining width of the cell-free zone at 12 h compared to the original width at 0 h (b); the data represented mean ± SEM% of three independent experiments. *Mean p < 0.05 compared to the control. Scale bars, 200 μm