Immunohistochemical phenotyping of T cells, granulocytes, and phagocytes in the muscle of cancer patients: association with radiologically defined muscle mass and gene expression

Table 2 Immunohistochemical identification and quantification of immune cells in the muscle

Immune cell identified	Antibodies	All (n = 30)	Males (n = 20)	Females (n = 10)
Immune cell identified	Antibodies	No. of cells per 100 fibers			p value
Granulocytes/phagocytes	CD11b+	1.6 (0–8)	1.6 (0–6)	1.6 (1–8)	0.98
a. Granulocytes/phagocytes subtype 1	CD11b+CD14+CD15+	1.0 (0–5)	1.3 (0–4)	0.5 (0–5)	0.32
b. Granulocytes/phagocytes subtype 2	CD11b+CD14−CD15−	0.5 (0–3)	0.0 (0–2)	1.1 (0–3)	0.14
T cells	CD3+	6.5 (1–24)	8.3 (1–24)	5.5 (1–12)	0.07
a. CD4 T cells	CD3+CD4+	2.3 (0–15)	2.7 (0–15)	1.7 (0–6)	0.05*
b. CD8 T cells	CD3+CD4−	4.1 (1–18)	5.6 (1–18)	4 (1–10)	0.21
CD3−CD4+ cells	CD3−CD4+	0.6 (0–12)	2.0 (0–6)	0.7 (0–12)	0.71

Values reported as median (range). p values from Mann-Whitney U test. *Difference between males and females (p = < 0.05)

ISSN: 2044-5040