Fig. 4

Lmcd1 overexpression alters several kinase activities in mouse primary myotubes related to skeletal muscle function. a Top 35 kinases interactions that significantly changed in a kinase activity assay in differentiated primary mouse myotubes after 2 days transduction with GFP (control) or LMCD1 adenovirus (n = 4). b Top 35 kinases scores, taking into account specificity and selectivity, that significantly changed in a kinase activity assay in myotubes transduced as in (a) (n = 4). c Top Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways of the top kinases that significantly changed in a kinase activity assay in myotubes transduced as in (a) (n = 4). d Top Reactome signaling pathways of the top kinases that significantly changed in a kinase activity assay in myotubes transduced as in (a) (n = 4). e Top Uniprot keywords of the top kinases that significantly changed in a kinase activity assay in myotubes transduced as in (a) (n = 4). EPHA1 Ephrin type-A receptor 1, CDK18 cyclin-dependent kinase 18, CDK11A cyclin-dependent kinase 11A, PRKCZ protein kinase C zeta, RPS6KA3 ribosomal protein S6 kinase A3, CDK17 cyclin-dependent kinase 17, CHEK1 checkpoint kinase 1, PRKDC protein kinase DNA-activated catalytic subunit, GSK3A glycogen synthase kinase-3 alpha, GSK3B glycogen synthase kinase-3 beta, EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3, IKBKB inhibitor of nuclear factor kappa B kinase subunit beta, CSNK1A1 casein kinase 1 alpha 1, CDK6 cyclin-dependent 6, RPS6KC1 ribosomal protein S6 kinase C1, HIPK4 homeodomain interacting protein kinase 4, CAMK2B calcium/calmodulin-dependent protein kinase II beta, MAPK11 mitogen-activated protein kinase 11, TBK1 tumor necrosis factor receptor-associated factor binding kinase 1, NRP2 neuropilin 2, DAPK2 death associated protein kinase 2, ICK intestinal cell kinase, RPS6KA4 ribosomal protein S6 kinase A4, GRK1 G protein-coupled receptor kinase 1, IKBKE inhibitor of nuclear factor kappa B kinase subunit epsilon, RPS6KA6 ribosomal protein S6 kinase A6, MAP2 K7 dual specificity mitogen-activated protein kinase 7, CAMK4 calcium/calmodulin-dependent protein kinase type IV, CDKL4 cyclin-dependent kinase Like 4, PLK2 polo like kinase 2, PLK3 polo like kinase 3, AURKB aurora kinase B, FoxO forkhead box, mTOR mammalian target of rapamycin