Fig. 2
From: A novel transplantable model of lung cancer-associated tissue loss and disrupted muscle regeneration
Lung cancer-associated inflammation. a Heat map of 29 cytokines profiled in the serum of vehicle or tumor-bearing mice. Features are sorted by the highest average of the tumor samples, from top to bottom. Values are the concentration, row normalized for each feature, then log2 transformed. Red = high expression, blue = low expression. b Bar graph of cytokines commonly associated with muscle wasting and/or cancer cachexia. Individual points represent individual animals. Boxes represent the inner quartile, and whiskers represent the minimum and maximum values. c Bar graph of cytokines significantly upregulated in tumor-bearing animals. Individual points represent individual animals. Boxes represent the inner quartile and whiskers represent the minimum and maximum values. *p < 0.05 in multiple t test with Holm-Sidak multiple testing correction. n = 5 vehicle, 4 tumor-bearing 7-week-old male 129S2/SvPasCrl mice