Fig. 11

Induced DUX4-fl expression causes regeneration of muscle fibers marked with eMyHC expression. Histological cross sections from TA muscles were dissected from mild, moderate, and severe FSHD-like model mice that had undergone treadmill exhaustion analysis 2× per week (see Figs. 7 and 8). Age-matched female control mice were used for the moderate model analysis and male control mice for the severe model analysis. Muscles were assayed from ACTA1-MCM TMX controls at a MD14, b SD3, and c SD9. Representative images of mild model (k, l, s, t), female moderate model (e–i and magnified images f–j), and male severe model (m–q and magnified images n–r) at indicated time point. Quantitative analysis of data is shown in Figure S12. Scale bars = 100 μm