Fig. 1
From: Functional effects of muscle PGC-1alpha in aged animals
PGC-1alpha promotes mitochondrial biogenesis and angiogenesis in 24-month-old mice. a Quantitative real time-polymerase chain Rreaction (qPCR) of PGC1 coactivators and components of the electron transport chain on quadriceps isolated from 4-month or 24-month-old wildtype and MCKa mice. b Western blots for oxidative phosphorylation proteins in quadriceps (quantification is normalized to total protein using amido black). c CD31 immunohistochemistry on tibialis anterior cryosections. d qPCR for endothelial markers and angiogenesis genes in quadriceps. e Myofiber minimal Feret diameter in tibialis anterior cryosections [n = 5, 4, 5, 5 for WT (4 mo), MCKa (4 mo), WT (24 mo), and MCKa (24 mo) respectively]. *P < 0.05 compared to control