Fig. 4

Basal regeneration is decreased in immunodeficient compared to immunocompetent mouse models of LAMA2-CMD. a Detection of embryonic Myosin Heavy Chain (eMHC) in TA sections of dy^W and NODScid dy^W mice. Quantification of eMHC-positive fibers in male (N = 7, 5, respectively; p value of 0.01; scale bar 100 μm) (b) and female (N = 5, 4, respectively; p value of 0.02). c dy^W and NODScid dy^W mice. Frequency histogram of minimum Feret’s diameters in TA muscle of male (N = 4, 5, respectively; p value < 0.0001) (d) and female (N = 5; p value < 0.0001) (e) dy^W and NODScid dy^W mice