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Table 2 Mechanical properties of IFM fibers from 2-day-old control and F437I heterozygote female flies

From: Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism

Line name (n) Pmax (W/m3) fmax (Hz) Ee at 500 Hz (kN/m2) Ef (Hz) Isometric Tension (mN/mm2) 2πb (s-1) 2πc (s-1)
pwMhc2/+pwMhc2 (13) 154 ± 9 184 ± 7 247 ± 20 279 ± 7 2.89 ± 0.22 1625 ± 89 2866 ± 129
F437I + pwMhc2 (12) 63 ± 7* 146 ± 7* 332 ± 43 236 ± 12* 4.43 ± 0.56* 1259 ± 109* 3276 ± 111*
  1. The mechanical properties ± standard errors of the mean of isolated mutant heterozygote and wild-type control fibers were assessed. Maximum power (Pmax), frequency where maximum power was generated (fmax), the frequency at lowest elastic modulus (Ef), isometric tension, and muscle apparent rate constants 2πb and 2πc were all significantly different for F437 heterozygote fibers compared to control fibers (* = P < 0.05, Student’s t test). Values are mean ± standard errors of the mean