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Fig. 3 | Skeletal Muscle

Fig. 3

From: A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy

Fig. 3

Plate 2 row D chemical pool, which includes TSA, significantly reduces the frequency of zebrafish dmd mutant animals exhibiting abnormal muscle birefringence. Control treatment is 1% DMSO. The dashed line represents the expected 25% affected animals. See Table 1 for the 10 chemicals in plate 2 row D. Each chemical was used at 1 μM. For each treatment condition, n = 3 replicates, with 23-27 embryos in each replicate. Error bars represent standard error. Significance was determined using a Mantel-Haenszel test. **p < 0.004 compared to DMSO control

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Skeletal Muscle

ISSN: 2044-5040

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