Fig. 4

Muscle degeneration of non-exercised WT, Nrf2^tKO, mdx, and Nrf2^tKOmdx mice. (a) Microscopic assessment of myofiber necrosis in GM using immunofluorescent staining of IgM and IgG (green) binding and (b) its calculation; n = 7-9. The activity of (c) LDH and (d) CK in plasma; activity assay; n = 3-6. The data are presented as mean +/− SEM; *p ≤ 0.05, one-way ANOVA with Tukey’s post hoc test; ##p ≤ 0.01 Student’s t test. The scale bars represent 100 μm