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Table 4 scRNA-seq gene signatures used for FAP identification and clustering in muscle homeostasis

From: Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors—time for new definitions

Genes/markers FAP subpopulations Species Reference
Sca1, Cd34, Pdgfra SubFAPs: Tie2low (Tek), Vcam1low Mouse [62]
SubFAPs: Tie2high (Tek), Vcam1high
Ly6a (Sca1), Ly6e, Pdgfra, Dcn Not determined Mouse [58]
Pdgfra, Ly6a (Sca1), Hic1 FAP1: Cxcl14, Col4, Col6, Col15, Lum, Sparcl1, Podn, Smoc2, Mgp, and Bgn Mouse [48]
FAP2: Dpp4, Sfrp4, Igfbp5, Sema3c, Tgfrb2, and Wnt2
Pdgfra, Ly6a (Sca1), Dcn, Cd34 Not determined Mouse [216]
Pdgfra, Col3a1, Dcn, and Gsn Not determined Mouse [107]
Pdgfra, Ly6a (Sca1), Cd34 FAP1: Cxcl14, Enpp2 (Autotaxin), Crispld2, Hsd11b1, Smoc2, Ccl11, Gsn, and Dcn Mouse [108]
FAP2: Dpp4, Pi16, Wnt2, Igfbp5, Igfbp6, Fbn1, and Ugdh
PDGFRA, CD34, COLLAGEN 1, COLLAGEN 3, and COLLAGEN 6 LUMICAN (LUM) FAP: LUM, DCN, CXCL14, COLLAGEN 4, and COLLAGEN 15, SMOC2, and GSN Mouse and human [109]
FIBRILLIN 1 (FBN1) FAP: FNB1, MFAP5, LOXL1, PRG4, ELN, IGFBP5, and FSTL1
PDGFRA FAP1 (fibroblasts 1): COL1A1, SFRP4, SERPINE1, and CCL2 Human [106]
FAP2 (Fibroblast 2): FBN1, MFAP5, and CD55
FAP3 (Fibroblast 3): SMOC2, ADH1B, and ABC18
PDGFRA, CD34, COL1A1, COL6A3, TCF7L2 FAP1: PCOLCE2, MFAP5, IGFBP6, ENNP1, CD55, and AXL Human [16] a
FAP2: LUM, MYOC, CCL2, ADH1B, SFRP2, CXCL14, and MGP
FAP3: TNXB, C3, COL15A1, SMOC2, ABCA8, COL6A1, and HMCN2
FAP4: IGF1, CRLF1, SCN7A, ITIH5, PTGDS and NOV
FAP5: SEMA3C, PRG4, DEFB1, CCDC80, LINC01133, and IGFBP5
  1. aBy re-clustering the FAP population, the authors described the existence of 7 different FAP subpopulations in human muscles [16]