Table 1 Summary of the mutants studied, and their human homologs, protein location, and reported behavioral phenotypes

uig-1(ok884)

Deletion, null

PLEKHG1, PLEKHG3

Dense bodies

Normal [27]

Normal [28]

Fast^a [28]

pfn-3(tm1362)

Deletion, null

Profilin

Dense bodies

Defective [27]

Slightly slow [43]

–

atn-1(ok84)

Deletion, null

α-Actinin

Dense bodies

Defective [27, 44]

Slow [28]

Normal^a [28]

alp-1(tm1137)

Deletion, null

Cypher/ZASP/ oracle

Dense bodies

Defective [27]

Normal [45]

–

dyc-1(cx32)

Unknown

Capon

Close to dense bodies

Overbent [46]

–

Fast [46]

dim-1(ra102)

Splice site; loss of function

–

Around and between dense bodies

Defective [27]

Slow [28]

Fast^a [28]

zyx-1(gk190)

Deletion, null

Zyxin

Dense bodies & M-lines

Defective [27]

–

–

tln-1(e259) previously, unc-35

Unknown

Talin

Dense bodies & M-lines

Overbent^b

–

Slow [47]

unc-95(su33)

Nonsense, null

–

Dense bodies & M-lines

Defective [27]

–

Slow [22]

pkn-1(ok1673)

Deletion, null

Protein kinase N

Dense bodies & M-lines

–

slow [48]

–

unc-82(e1220)

Missense

ARK5 & SNARK protein kinases

M-lines

–

–

Slow [47]

unc-89(e1460)

Nonsense in alternatively spliced exon; hypomorph

Obscurin

M-lines

–

Slow [49]

Slow [49]

unc-98(sf19)

splice site;

loss of function

–

M-lines

Normal [27]

Slow [28, 50]

Normal [28]

unc-22(sf21)

Missense

Titin family member

Thick filaments

–

Fast [51]

Fast [51]

unc-22(e66)

2 bp deletion; frame-shift to nonsense; loss of function

Titin family member

Thick filaments

–

Slow [28, 51]

Slow [51]

unc-54(s95)

missense

Myosin heavy chain

Thick filaments

–

–

Slow [52]

unc-54(s74)

missense

Myosin heavy chain

Thick filaments

–

Slow [28]

Slow [28, 52]

lev-11(x12)

Missense

note: null is Pat embryonic lethal

Tropomyosin

Thin filaments

–

Normal [28]

Fast^a [28]

unc-60(r398)

Nonsense near C-terminus; loss of function

ADF/cofilin

Thin filaments

–

Slow [28, 53]

Slow^a [28]

unc-94(sf20)

Nonsense; null

Tropomodulin

Thin filaments

–

Slow [54]

–