Fig. 6
From: Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight
DAS of transcripts encoding giant sarcomeric proteins during spaceflight. A Ttn, D Obscn, and G Neb pre-mRNA transcript representations. Colored regions represent encoded protein domains described in the legends provided. Solid numbers represent the number of statistically significant DAS events within the corresponding region of interest in the gastrocnemius (top) and quadriceps (bottom). Line graphs display â–³PSI (change in percent spliced in of a specific exon) values for exons encoding the Ttn PEVK domain (exons 122-202), Obscn splicing variable region (SVR) (exons 40-52), and Neb C-terminal variable region (exons 120-160), respectively, that underwent significant DAS between ground control and flight groups in the gastrocnemius (B, E, H, respectively) and quadriceps (C, F, I, respectively). Positive â–³PSI events represent exons that were included more in the flight group while negative â–³PSI value events represent exons that were included less in the flight group. Non-significantly alternatively spliced exons were assigned a â–³PSI value of 0. Average â–³PSI across statistically significant events are provided