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Fig. 6 | Skeletal Muscle

Fig. 6

From: Absence of the Z-disc protein α-actinin-3 impairs the mechanical stability of Actn3KO mouse fast-twitch muscle fibres without altering their contractile properties or twitch kinetics

Fig. 6

Contraction-induced breakages are more pronounced in EDL fibres from Actn3KO mice. a Schematic of the eccentric contractions protocol, maximally activating a single fibre and then imposing a 20% stretch before returning to resting length L0 and subsequent relaxation. Three eccentric contractions were carried out followed by a final assessment of maximum isometric force. b Actn3KO fibres showed much lower survival and higher rate of breakage during the sequence to a significance of p = 0.02 based on logrank analysis. In b, fibres that broke are shown in the segments of the pie chart with diagonal lines, while nonbreaking fibres are shown in solid fill

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Skeletal Muscle

ISSN: 2044-5040

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