Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice

Meijboom, Katharina E.; Sutton, Emma R.; McCallion, Eve; McFall, Emily; Anthony, Daniel; Edwards, Benjamin; Kubinski, Sabrina; Tapken, Ines; Bünermann, Ines; Hazell, Gareth; Ahlskog, Nina; Claus, Peter; Davies, Kay E.; Kothary, Rashmi; Wood, Matthew J. A.; Bowerman, Melissa

doi:10.1186/s13395-022-00301-z

Skeletal Muscle

Table 1 Myogenesis and myopathy genes significantly dysregulated in the same direction in triceps and quadriceps of P7 Smn^−/−;SMN2, Fn14^−/− and Tweak^−/− mice when compared to P7 WT mice

From: Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice

		*Triceps*						*Quadriceps*
		*Smn^−/−;SMN2*		*Fn14*^−/−		*Tweak*^−/−		*Smn^−/−;SMN2*		*Fn14*^−/−		*Tweak*^−/−
Gene		*Fold change*	*p-value*	*Fold change*	*p-value*	*Fold change*	*p-value*	*Fold change*	*p-value*	*Fold change*	*p-value*	*Fold change*	*p-value*
Crystallin alpha B (Cryab)	Up	1.3245	0.002813	1.3814	0.010565	1.3711	0.041543	1.386	0.013894	1.2332	0.000616		ns
Dystroglycan 1 (Dag1)	Down	↑		−1.1823	0.008415	−1.3607	0.001058	−1.3575	0.039065	−1.1416	0.003343	−1.4885	0.001277
Insulin-like growth factor binding protein 5 (Igfbp5)	Down	-6.5548	0	−1.6343	0.000135	−1.2758	0.008243	−8.0095	0.000017	−1.2813	0.006583		ns
Myogenic factor 6 (Myf6)	Up	↓		1.1221	0.008823	1.6485	0.003036	1.0137	0.831317		ns	1.4051	0.006745
Myogenic differentiation 1 (Myod1)	Up	↓		1.2595	0.046953	1.91	0.000369	↓			ns		ns
Paired Box 7 (Pax7)	Down	−1.7035	0.000189	−1.1814	0.001774	−1.1522	0.014681	−2.4268	0.000151		ns		ns
Protein kinase AMP-activated non-catalytic subunit gamma 3 (Prkag3)	Down	−13.700	0	−1.7401	0.002101	−1.6191	0.001641	−8.0475	0.000019	−1.6521	0.005939	−1.6346	0.006477
Pyruvate dehydrogenase kinase 4 (Pdk4)	Up	7.7734	0.005328	1.8326	0.01063	2.209	0.004106	5.3978	0.055184	1.9628	0.006922	1.5978	0.003346
Ribosomal protein S6 kinase B1 (Rps6kb1)	Down	−1.1105	0.045173	−1.1183	0.012509	−1.335	0.006426	−1.541	0.012036	−1.1078	0.027897	−1.4257	0.000143
Titin (Ttn)	Down	−1.4206	0.000015	−1.1322	0.023526		ns	−1.8247	0.000386	−1.1965	0.01243	−1.2861	0.001181

Ns not significant, ↑significantly upregulated, ↓significantly downregulated. Fold change (2^(-delta-delta CT)) is the normalized gene expression (2^(-delta CT)) in the test sample divided the normalized gene expression (2^(-delta CT)) in the WT samples. Fold-change values greater than 1 indicate a positive- or an upregulation and the fold regulation is equal to the fold change. Fold-change values less than 1 indicate a negative or downregulation and the fold regulation is the negative inverse of the fold change. The p-values are calculated based on a Student’s t-test of the replicate 2^(-delta CT) values for each gene in the control group and treatment groups

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