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Fig. 7 | Skeletal Muscle

Fig. 7

From: Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways

Fig. 7

Validation of signaling and mechanosensitive pathways increased in mdxTG muscle. Indirect immunofluorescence analysis and quantification of 12-week-old mouse quadriceps using antibodies against (a) collagen II (Col II) and collagen V (Col V), (b)β-spectrin (Sptbn1), (c) yes-associated protein 1 (Yap1) and SRY-Box transcription factor 9 (Sox9) showing increased abundance in mdxTG relative to both WT and mdx. Sox9 is expressed at the neuromuscular junction shown by co-localization with α-bungarotoxin (α-BgTx). Statistical analyses were performed by one-way ANOVA with Tukey’s multiple comparison tests, n = 3–4 biological replicates per genotype, data represented as +/− SEM (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). Scale bar = 100 μm

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Skeletal Muscle

ISSN: 2044-5040

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