Sarcopenia: investigation of metabolic changes and its associated mechanisms

Skeletal Muscle

Table 2 Results from the linear models for the associations between the plasma metabolites with (A) insulin-like growth factor I (IGF-I) and (B) IGF-I/insulin-like growth factor-binding protein (IGFBP3) in the study population

Class	Metabolite	Regression coefficient (β)	P value	P value (after FDR correction)
A. Insulin-like growth factor I (IGF-I)
AA	Cit	−0.024	0.016	ns
NEFA	NEFA.26:2	−0.021	0.043	ns
	NEFA.24:4	−0.02	0.045	ns
	NEFA.24:2	−0.02	0.05	ns
B. IGF-I/insulin-like growth factor BP3
NEFA	NEFA.13:0	−0.181	0.001	ns
	NEFA.17:1	−0.165	0.004	ns
	NEFA.16:1	−0.164	0.004	ns
	NEFA.14:1	−0.163	0.005	ns
	NEFA.12:1	−0.16	0.006	ns
	NEFA.19:1	−0.156	0.007	ns
	NEFA.16:3	−0.15	0.011	ns
	NEFA.16:0	−0.149	0.011	ns
	NEFA.22:2	−0.143	0.015	ns
	NEFA.18:2	−0.143	0.016	ns
	NEFA.14:2	−0.141	0.017	ns
	NEFA.24:4	−0.138	0.02	ns
	NEFA.22:4	−0.136	0.022	ns
	NEFA.14:0	−0.133	0.026	ns
	NEFA.24:3	−0.127	0.034	ns
	NEFA.22:3	−0.121	0.047	ns
	NEFA.24:2	−0.127	0.034	ns
Carn.a	Carn.3.0	0.125	0.038	ns

AA amino acids, Carn.a acylcarnitines, NEFA non-esterified fatty acids. P values as ns non-significant

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