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Figure 3 | Skeletal Muscle

Figure 3

From: X-linked myotubular myopathy in Rottweiler dogs is caused by a missense mutation in Exon 11 of the MTM1 gene

Figure 3

Abnormal staining patterns for triad proteins and markers of autophagy in skeletal muscles from affected dogs. (A) Immunofluorescence staining of cryosections from the biceps femoris muscles of Rottweiler puppies affected with XLMTM (puppies III-12 and III-14). Irregular staining patterns were noted in affected puppies using antibodies against DHPRα1 (T-tubule marker) and RyR1 (SR marker) compared to control muscle. (B) Compared to control muscle, dense and irregular staining patterns were also noted following staining with the autophagy markers LC3 and ubiquitin.

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Skeletal Muscle

ISSN: 2044-5040

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