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Research
Limb-girdle muscular dystrophies (LGMDs) are a heterogeneous group of inherited autosomal myopathies that preferentially affect voluntary muscles of the shoulders and hips. LGMD has been clinically described i...
Skeletal Muscle 2017 7:15
Published on: 11 July 2017
Research
Pax7+ satellite cells are required for skeletal muscle fiber growth during post-natal development in mice. Satellite cell-mediated myonuclear accretion also appears to persist into early adulthood. Given the i...
Skeletal Muscle 2017 7:14
Published on: 10 July 2017
Research
Facioscapulohumeral muscular dystrophy (FSHD) is most commonly inherited in an autosomal dominant pattern and caused by the abnormal expression of DUX4 in skeletal muscle. The DUX4 transcription factor has DNA...
Skeletal Muscle 2017 7:13
Published on: 21 June 2017
Research
Sarcospan (SSPN) is a transmembrane protein that interacts with the sarcoglycans (SGs) to form a tight subcomplex within the dystrophin-glycoprotein complex that spans the sarcolemma and interacts with laminin...
Skeletal Muscle 2017 7:11
Published on: 6 June 2017
Research
Facioscapulohumeral muscular dystrophy (FSHD) is in most cases caused by a contraction of the D4Z4 macrosatellite repeat on chromosome 4 (FSHD1) or by mutations in the SMCHD1 or DNMT3B gene (FSHD2). Both situatio...
Skeletal Muscle 2017 7:12
Published on: 6 June 2017
Research
The terminal pathway of the innate immune complement system is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Terminal complement activation leads to generation of C5a, which through it...
Skeletal Muscle 2017 7:10
Published on: 1 June 2017
Review
Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in the DMD gene and loss of the protein dystrophin. The absence of dystrophin leads to myofiber membrane fragility and necrosis, with e...
Skeletal Muscle 2017 7:9
Published on: 19 May 2017
Research
shRNA lentiviral vectors are extensively used for gene knockdowns in mammalian cells, and non-target shRNAs typically are considered the proper experimental control for general changes caused by RNAi. However,...
Skeletal Muscle 2017 7:7
Published on: 15 May 2017
Research
We previously reported that Wnt5a/CaMKIIδ (calcium/calmodulin-dependent protein kinase II delta) pathway was involved in the embryonic tongue deformity induced by excess retinoic acid (RA). Our latest study fo...
Skeletal Muscle 2017 7:8
Published on: 11 May 2017
Research
Motor neurons control muscle contraction by initiating action potentials in muscle. Denervation of muscle from motor neurons leads to muscle atrophy, which is linked to mitochondrial dysfunction. It is known t...
Skeletal Muscle 2017 7:6
Published on: 10 April 2017
Research
The spatial organization of eukaryotic genomes facilitates and reflects the underlying nuclear processes that are occurring in the cell. As such, the spatial organization of a genome represents a window on the...
Skeletal Muscle 2017 7:5
Published on: 5 April 2017
Erratum
Skeletal Muscle 2017 7:4
Published on: 15 February 2017
The original article was published in Skeletal Muscle 2016 6:45
Research
The Ste20-like kinase, SLK, plays an important role in cell proliferation and cytoskeletal remodeling. In fibroblasts, SLK has been shown to respond to FAK/Src signaling and regulate focal adhesion turnover th...
Skeletal Muscle 2017 7:3
Published on: 2 February 2017
Research
Although skeletal muscle wasting has long been observed as a clinical outcome of impaired vitamin D signaling, precise molecular mechanisms that mediate the loss of muscle mass in the absence of vitamin D sign...
Skeletal Muscle 2017 7:2
Published on: 25 January 2017
Methodology
Fatty infiltration of the skeletal muscle is a common but poorly understood feature of many myopathies. It is best described in human muscle, where non-invasive imaging techniques and representative histology ...
Skeletal Muscle 2017 7:1
Published on: 10 January 2017
Research
There is much interest in the capacity of resistance exercise to prevent the age-related loss of skeletal muscle mass and function, known as sarcopenia. This study investigates the molecular basis underlying t...
Skeletal Muscle 2016 6:45
Published on: 13 December 2016
The Erratum to this article has been published in Skeletal Muscle 2017 7:4
Research
Large-scale expansion of myogenic progenitors is necessary to support the development of high-throughput cellular assays in vitro and to advance genetic engineering approaches necessary to develop cellular the...
Skeletal Muscle 2016 6:44
Published on: 13 December 2016
Research
hTERT/cdk4 immortalized myogenic human cell lines represent an important tool for skeletal muscle research, being used as therapeutically pertinent models of various neuromuscular disorders and in numerous fun...
Skeletal Muscle 2016 6:43
Published on: 8 December 2016
Research
Postnatal growth and repair of skeletal muscle relies upon a population of quiescent muscle precursor cells, called satellite cells that can be activated to proliferate and differentiate into new myofibers, as...
Skeletal Muscle 2016 6:40
Published on: 7 December 2016
Research
The myogenic capacity of satellite cells (SCs), adult muscle stem cells, is influenced by aging, exercise, and other factors. In skeletal muscle, the peroxisome proliferator-activated receptor γ coactivator 1α...
Skeletal Muscle 2016 6:39
Published on: 2 December 2016
Research
Nuclear bodies, such as nucleoli, PML bodies, and SC35 speckles, are dynamic sub-nuclear structures that regulate multiple genetic and epigenetic processes. Additional regulation is provided by RNA/DNA handlin...
Skeletal Muscle 2016 6:42
Published on: 1 December 2016
Research
Duchenne muscle dystrophy (DMD) is one of the most common lethal genetic diseases of children worldwide and is 100% fatal. Steroids, the only therapy currently available, are marred by poor efficacy and a high...
Skeletal Muscle 2016 6:41
Published on: 28 November 2016
Research
Skeletal muscle tissue has an enormous regenerative capacity that is instrumental for a successful defense against muscle injury and wasting. The peroxisome proliferator-activated receptor γ coactivator 1α (PG...
Skeletal Muscle 2016 6:38
Published on: 8 November 2016
Research
Fluorescent-activated cell sorting (FACS) has enabled the direct isolation of highly enriched skeletal muscle stem cell, or satellite cell, populations from postnatal tissue. Several distinct surface marker pa...
Skeletal Muscle 2016 6:35
Published on: 8 November 2016
Erratum
Skeletal Muscle 2016 6:37
Published on: 31 October 2016
The original article was published in Skeletal Muscle 2015 5:5
