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  1. ALAS2 (delta-aminolevulinate synthase 2) is one of the two isoenzymes catalyzing the synthesis of delta-aminolevulinic acid (ALA), which is the first precursor of heme synthesis. ALAS2-overexpressing transgeni...

    Authors: Yahui Peng, Jihong Li, Dixian Luo, Shuai Zhang, Sijia Li, Dayong Wang, Xidi Wang, Zhujun Zhang, Xue Wang, Changhui Sun, Xu Gao, Yang Hui and Rongzhang He

    Citation: Skeletal Muscle 2021 11:9

    Content type: Research

    Published on:

  2. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Adeel Safdar, Konstantin Khrapko, James M. Flynn, Ayesha Saleem, Michael De Lisio, Adam P. W. Johnston, Yevgenya Kratysberg, Imtiaz A. Samjoo, Yu Kitaoka, Daniel I. Ogborn, Jonathan P. Little, Sandeep Raha, Gianni Parise, Mahmood Akhtar, Bart P. Hettinga, Glenn C. Rowe…

    Citation: Skeletal Muscle 2021 11:8

    Content type: Retraction Note

    Published on:

    The original article was published in Skeletal Muscle 2016 6:7

  3. Satellite cells (SCs) are muscle stem cells capable of regenerating injured muscle. The study of their functional potential depends on the availability of methods for the isolation and expansion of pure SCs wi...

    Authors: Anna Benedetti, Gianluca Cera, Daniele De Meo, Ciro Villani, Marina Bouche and Biliana Lozanoska-Ochser

    Citation: Skeletal Muscle 2021 11:7

    Content type: Methodology

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  4. Sarcopenia is a common skeletal disease related to myogenic disorders and muscle atrophy. Current clinical management has limited effectiveness. We sought to investigate the role of miR-1290 in myoblast differ...

    Authors: Ji Che, Cuidi Xu, Yuanyuan Wu, Peiyu Jia, Qi Han, Yantao Ma, Xiaolei Wang and Yongjun Zheng

    Citation: Skeletal Muscle 2021 11:6

    Content type: Research

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  5. Myogenin is a transcription factor that is expressed during terminal myoblast differentiation in embryonic development and adult muscle regeneration. Investigation of this cell state transition has been hampered ...

    Authors: Maria Benavente-Diaz, Glenda Comai, Daniela Di Girolamo, Francina Langa and Shahragim Tajbakhsh

    Citation: Skeletal Muscle 2021 11:5

    Content type: Methodology

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  6. Almost every muscle contains muscle spindles. These delicate sensory receptors inform the central nervous system (CNS) about changes in the length of individual muscles and the speed of stretching. With this i...

    Authors: Stephan Kröger and Bridgette Watkins

    Citation: Skeletal Muscle 2021 11:3

    Content type: Review

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  7. A cohort of related miniature dachshund dogs with exercise intolerance, stiff gait, dysphagia, myoglobinuria, and markedly elevated serum creatine kinase activities were identified.

    Authors: James R. Mickelson, Katie M. Minor, Ling T. Guo, Steven G. Friedenberg, Jonah N. Cullen, Amanda Ciavarella, Lydia E. Hambrook, Karen M. Brenner, Sarah E. Helmond, Stanley L. Marks and G. Diane Shelton

    Citation: Skeletal Muscle 2021 11:2

    Content type: Research

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  8. Nonsense or loss-of-function mutations in the non-lysosomal cysteine protease calpain-3 result in limb-girdle muscular dystrophy type 2A (LGMD2A). While calpain-3 is implicated in muscle cell differentiation, ...

    Authors: Vanessa E. Jahnke, Jennifer M. Peterson, Jack H. Van Der Meulen, Jessica Boehler, Kitipong Uaesoontrachoon, Helen K. Johnston, Aurelia Defour, Aditi Phadke, Qing Yu, Jyoti K. Jaiswal and Kanneboyina Nagaraju

    Citation: Skeletal Muscle 2020 10:37

    Content type: Research

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  9. The nuclear factor erythroid 2-related factor 2 (Nrf2) is considered as a master cytoprotective factor regulating the expression of genes encoding anti-oxidant, anti-inflammatory, and detoxifying proteins. The...

    Authors: Iwona Bronisz-Budzyńska, Magdalena Kozakowska, Paulina Podkalicka, Neli Kachamakova-Trojanowska, Agnieszka Łoboda and Józef Dulak

    Citation: Skeletal Muscle 2020 10:35

    Content type: Research

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  10. Tetraspanins are a family of proteins known to assemble protein complexes at the cell membrane. They are thought to play diverse cellular functions in tissues by modifying protein-binding partners, thus bringi...

    Authors: Arielle Hall, Tatiana Fontelonga, Alec Wright, Katlynn Bugda Gwilt, Jeffrey Widrick, Alessandra Pasut, Francesco Villa, Cynthia K. Miranti, Devin Gibbs, Evan Jiang, Hui Meng, Michael W. Lawlor and Emanuela Gussoni

    Citation: Skeletal Muscle 2020 10:34

    Content type: Research

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  11. The RYR1 gene, which encodes the sarcoplasmic reticulum calcium release channel or type 1 ryanodine receptor (RyR1) of skeletal muscle, was sequenced in 1988 and RYR1 variations that impair calcium homeostasis an...

    Authors: Tokunbor A. Lawal, Joshua J. Todd, Jessica W. Witherspoon, Carsten G. Bönnemann, James J. Dowling, Susan L. Hamilton, Katherine G. Meilleur and Robert T. Dirksen

    Citation: Skeletal Muscle 2020 10:32

    Content type: Review

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  12. Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain la...

    Authors: David W. Frederick, Alan V. McDougal, Melisa Semenas, Johanna Vappiani, Andrea Nuzzo, John C. Ulrich, J. David Becherer, Frank Preugschat, Eugene L. Stewart, Daniel C. Sévin and H. Fritz Kramer

    Citation: Skeletal Muscle 2020 10:30

    Content type: Research

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  13. Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder and is one of the most common muscular dystrophies. There are currently few effective therapies to treat the disease, although many small-mo...

    Authors: Gist H. Farr III, Melanie Morris, Arianna Gomez, Thao Pham, Elisabeth Kilroy, Elizabeth U. Parker, Shery Said, Clarissa Henry and Lisa Maves

    Citation: Skeletal Muscle 2020 10:29

    Content type: Research

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  14. Satellite cells are the canonical muscle stem cells that regenerate damaged skeletal muscle. Loss of function of these cells has been linked to reduced muscle repair capacity and compromised muscle health in a...

    Authors: Sean M. Buchanan, Feodor D. Price, Alessandra Castiglioni, Amanda Wagner Gee, Joel Schneider, Mark N. Matyas, Monica Hayhurst, Mohammadsharif Tabebordbar, Amy J. Wagers and Lee L. Rubin

    Citation: Skeletal Muscle 2020 10:28

    Content type: Research

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  15. Facioscapulohumeral muscular dystrophy (FSHD) is a skeletal muscle disorder that is caused by derepression of the transcription factor DUX4 in skeletal muscle cells. Apart from SMCHD1, DNMT3B was recently iden...

    Authors: Linde F. Bouwman, Bianca den Hamer, Elwin P. Verveer, Lente J. S. Lerink, Yvonne D. Krom, Silvère M. van der Maarel and Jessica C. de Greef

    Citation: Skeletal Muscle 2020 10:27

    Content type: Research

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  16. Duchenne muscular dystrophy (DMD) is a degenerative muscle disease caused by mutations in the dystrophin gene. Loss of dystrophin prevents the formation of a critical connection between the muscle cell membran...

    Authors: Cynthia Shu, Liubov Parfenova, Ekaterina Mokhonova, Judd R. Collado, Robert Damoiseaux, Jesus Campagna, Varghese John and Rachelle H. Crosbie

    Citation: Skeletal Muscle 2020 10:26

    Content type: Research

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  17. Elderly populations are susceptible to critical limb ischemia (CLI), but conventional treatments cannot significantly decrease amputation and mortality. Although exercise is an effective “non-pharmacological m...

    Authors: Wuyang He, Peng Wang, Qingwei Chen and Chunqiu Li

    Citation: Skeletal Muscle 2020 10:25

    Content type: Research

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  18. Distal arthrogryposis (DA) is a group of autosomal dominant skeletal muscle diseases characterized by congenital contractures of distal limb joints. The most common cause of DA is a mutation of the embryonic m...

    Authors: Yiming Guo, William A. Kronert, Karen H. Hsu, Alice Huang, Floyd Sarsoza, Kaylyn M. Bell, Jennifer A. Suggs, Douglas M. Swank and Sanford I. Bernstein

    Citation: Skeletal Muscle 2020 10:24

    Content type: Research

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  19. Canine models of Duchenne muscular dystrophy (DMD) are a valuable tool to evaluate potential therapies because they faithfully reproduce the human disease. Several cases of dystrophinopathies have been describ...

    Authors: Inès Barthélémy, Nadège Calmels, Robert B. Weiss, Laurent Tiret, Adeline Vulin, Nicolas Wein, Cécile Peccate, Carole Drougard, Christophe Beroud, Nathalie Deburgrave, Jean-Laurent Thibaud, Catherine Escriou, Isabel Punzón, Luis Garcia, Jean-Claude Kaplan, Kevin M. Flanigan…

    Citation: Skeletal Muscle 2020 10:23

    Content type: Research

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  20. Satellite cells (SCs) are required for muscle repair following injury and are involved in muscle remodeling upon muscular contractions. Exercise stimulates SC accumulation and myonuclear accretion. To what ext...

    Authors: Evi Masschelein, Gommaar D’Hulst, Joel Zvick, Laura Hinte, Inés Soro-Arnaiz, Tatiane Gorski, Ferdinand von Meyenn, Ori Bar-Nur and Katrien De Bock

    Citation: Skeletal Muscle 2020 10:21

    Content type: Research

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  21. Skeletal muscle is increasingly considered an endocrine organ secreting myokines and extracellular vesicles (exosomes and microvesicles), which can affect physiological changes with an impact on different path...

    Authors: Laura Le Gall, Zamalou Gisele Ouandaogo, Ekene Anakor, Owen Connolly, Gillian Butler Browne, Jeanne Laine, William Duddy and Stephanie Duguez

    Citation: Skeletal Muscle 2020 10:20

    Content type: Methodology

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  22. Single-cell RNA-sequencing (scRNA-seq) facilitates the unbiased reconstruction of multicellular tissue systems in health and disease. Here, we present a curated scRNA-seq dataset of human muscle samples from 1...

    Authors: Andrea J. De Micheli, Jason A. Spector, Olivier Elemento and Benjamin D. Cosgrove

    Citation: Skeletal Muscle 2020 10:19

    Content type: Research

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  23. Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating genetic disease caused by mutations in the LAMA2 gene. These mutations result in progressive muscle wasting and inflammation leadin...

    Authors: Pamela Barraza-Flores, Hailey J. Hermann, Christina R. Bates, Tyler G. Allen, Timothy T. Grunert and Dean J. Burkin

    Citation: Skeletal Muscle 2020 10:18

    Content type: Research

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  24. Skeletal muscle function is essential for health, and it depends on the proper activity of myofibers and their innervating motor neurons. Each adult muscle is composed of different types of myofibers with dist...

    Authors: Tania Incitti, Alessandro Magli, Asher Jenkins, Karena Lin, Ami Yamamoto and Rita C. R. Perlingeiro

    Citation: Skeletal Muscle 2020 10:17

    Content type: Research

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  25. Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by loss of alpha motor neurons and skeletal muscle atrophy. The disease is caused by mutations of the SMN1 gene that result in reduced fu...

    Authors: Guzal Khayrullina, Kasey E. Moritz, James F. Schooley, Naheed Fatima, Coralie Viollet, Nikki M. McCormack, Jeremy T. Smyth, Martin L. Doughty, Clifton L. Dalgard, Thomas P. Flagg and Barrington G. Burnett

    Citation: Skeletal Muscle 2020 10:16

    Content type: Research

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  26. The arrangement of myonuclei in skeletal muscle tissue has long been used as a biomarker for muscle health, but there is a dearth of in vivo exploration of potential effects of myonuclear organization on the f...

    Authors: Robert Louis Hastings, Ryan T. Massopust, Seth G. Haddix, Young il Lee and Wesley J. Thompson

    Citation: Skeletal Muscle 2020 10:15

    Content type: Methodology

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  27. PGC-1 (peroxisome-proliferator-activated receptor-γ coactivator-1) alpha is a potent transcriptional coactivator that coordinates the activation of numerous metabolic processes. Exercise strongly induces PGC-1...

    Authors: Steven Yang, Emanuele Loro, Shogo Wada, Boa Kim, Wei-Ju Tseng, Kristina Li, Tejvir S. Khurana and Zoltan Arany

    Citation: Skeletal Muscle 2020 10:14

    Content type: Research

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  28. In Duchenne muscular dystrophy (DMD), DYSTROPHIN deficiency exposes myofibers to repeated cycles of contraction/degeneration, ultimately leading to muscle loss and replacement by fibrotic tissue. DMD pathology...

    Authors: Luca Caputo, Alice Granados, Jessica Lenzi, Alessandro Rosa, Slimane Ait-Si-Ali, Pier Lorenzo Puri and Sonia Albini

    Citation: Skeletal Muscle 2020 10:13

    Content type: Research

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  29. Pulmonary hypertension leads to right ventricular heart failure and ultimately to cardiac cachexia. Cardiac cachexia induces skeletal muscles atrophy and contractile dysfunction. MAFbx and MuRF1 are two key pr...

    Authors: Thanh Nguyen, T. Scott Bowen, Antje Augstein, Antje Schauer, Alexander Gasch, Axel Linke, Siegfried Labeit and Volker Adams

    Citation: Skeletal Muscle 2020 10:12

    Content type: Research

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  30. Transforming growth factor beta (TGF-β)-Smad2/3 is the major signaling pathway of fibrosis, which is characterized by the excessive production and accumulation of extracellular matrix (ECM) components, includi...

    Authors: Naoya Kakutani, Shingo Takada, Hideo Nambu, Junichi Matsumoto, Takaaki Furihata, Takashi Yokota, Arata Fukushima and Shintaro Kinugawa

    Citation: Skeletal Muscle 2020 10:11

    Content type: Research

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  31. Defects in α-dystroglycan (DG) glycosylation characterize a group of muscular dystrophies known as dystroglycanopathies. One of the key effectors in the α-DG glycosylation pathway is the glycosyltransferase fu...

    Authors: Karim Azzag, Carolina Ortiz-Cordero, Nelio A. J. Oliveira, Alessandro Magli, Sridhar Selvaraj, Sudheer Tungtur, Weston Upchurch, Paul A. Iaizzo, Qi Long Lu and Rita C. R. Perlingeiro

    Citation: Skeletal Muscle 2020 10:10

    Content type: Research

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  32. Following the publication of this paper [1], it was brought to the authors’ attention that one of the contributing authors was left off of the paper. The authors apologize for the unfortunate oversight. In thi...

    Authors: Frank Li, Justin Kolb, Julie Crudele, Paola Tonino, Zaynab Hourani, John E. Smith III, Jeffrey S. Chamberlain and Henk Granzier

    Citation: Skeletal Muscle 2020 10:9

    Content type: Correction

    Published on:

    The original article was published in Skeletal Muscle 2020 10:2

  33. All types of facioscapulohumeral muscular dystrophy (FSHD) are caused by the aberrant activation of the somatically silent DUX4 gene, the expression of which initiates a cascade of cellular events ultimately lead...

    Authors: Takako I. Jones, Guo-Liang Chew, Pamela Barraza-Flores, Spencer Schreier, Monique Ramirez, Ryan D. Wuebbles, Dean J. Burkin, Robert K. Bradley and Peter L. Jones

    Citation: Skeletal Muscle 2020 10:8

    Content type: Research

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  34. Skeletal muscles are composed of a heterogeneous collection of fiber types with different physiological adaption in response to a stimulus and disease-related conditions. Each fiber has a specific molecular ex...

    Authors: Sebastian Kallabis, Lena Abraham, Stefan Müller, Verena Dzialas, Clara Türk, Janica Lea Wiederstein, Theresa Bock, Hendrik Nolte, Leonardo Nogara, Bert Blaauw, Thomas Braun and Marcus Krüger

    Citation: Skeletal Muscle 2020 10:7

    Content type: Methodology

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  35. Cancer-associated muscle wasting (CAW), a symptom of cancer cachexia, is associated with approximately 20% of lung cancer deaths and remains poorly characterized on a mechanistic level. Current animal models f...

    Authors: Paige C. Arneson-Wissink, Alexandra M. Ducharme and Jason D. Doles

    Citation: Skeletal Muscle 2020 10:6

    Content type: Research

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  36. Hexose-6-Phosphate Dehydrogenase (H6PD) is a generator of NADPH in the Endoplasmic/Sarcoplasmic Reticulum (ER/SR). Interaction of H6PD with 11β-hydroxysteroid dehydrogenase type 1 provides NADPH to support oxo...

    Authors: Craig L. Doig, Agnieszka E. Zielinska, Rachel S. Fletcher, Lucy A. Oakey, Yasir S. Elhassan, Antje Garten, David Cartwright, Silke Heising, Ahmed Alsheri, David G. Watson, Cornelia Prehn, Jerzy Adamski, Daniel A. Tennant and Gareth G. Lavery

    Citation: Skeletal Muscle 2020 10:5

    Content type: Research

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  37. Skeletal muscle is among the most age-sensitive tissues in mammal organisms. Significant changes in its resident stem cells (i.e., satellite cells, SCs), differentiated cells (i.e., myofibers), and extracellul...

    Authors: Jessy Etienne, Chao Liu, Colin M. Skinner, Michael J. Conboy and Irina M. Conboy

    Citation: Skeletal Muscle 2020 10:4

    Content type: Review

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  38. Dystrophin deficiency sensitizes skeletal muscle of mice to eccentric contraction (ECC)-induced strength loss. ECC protocols distinguish dystrophin-deficient from healthy, wild type muscle, and test the effica...

    Authors: Angus Lindsay, Cory W. Baumann, Robyn T. Rebbeck, Samantha L. Yuen, William M. Southern, James S. Hodges, Razvan L. Cornea, David D. Thomas, James M. Ervasti and Dawn A. Lowe

    Citation: Skeletal Muscle 2020 10:3

    Content type: Research

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  39. Nebulin is a critical thin filament-binding protein that spans from the Z-disk of the skeletal muscle sarcomere to near the pointed end of the thin filament. Its massive size and actin-binding property allows ...

    Authors: Frank Li, Justin Kolb, Julie Crudele, Paola Tonino, Zaynab Hourani, John E. Smith III, Jeffrey S. Chamberlain and Henk Granzier

    Citation: Skeletal Muscle 2020 10:2

    Content type: Research

    Published on:

    The Correction to this article has been published in Skeletal Muscle 2020 10:9

  40. Skeletal muscle atrophy is the net loss of muscle mass that results from an imbalance in protein synthesis and protein degradation. It occurs in response to several stimuli including disease, injury, starvatio...

    Authors: Clayton Whitmore, Evan P.S. Pratt, Luke Anderson, Kevin Bradley, Sawyer M. Latour, Mariam N. Hashmi, Albert K. Urazaev, Rod Weilbaecher, Judith K. Davie, Wen-Horng Wang, Gregory H. Hockerman and Amber L. Pond

    Citation: Skeletal Muscle 2020 10:1

    Content type: Research

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  41. Duchenne muscular dystrophy (DMD) is caused by loss of sarcolemma connection to the extracellular matrix. Transgenic overexpression of the transmembrane protein sarcospan (SSPN) in the DMD mdx mouse model signifi...

    Authors: Cynthia Shu, Ariana N. Kaxon-Rupp, Judd R. Collado, Robert Damoiseaux and Rachelle H. Crosbie

    Citation: Skeletal Muscle 2019 9:32

    Content type: Research

    Published on:

  42. Myogenesis is driven by specific changes in the transcriptome that occur during the different stages of muscle differentiation. In addition to controlled transcriptional transitions, several other post-transcr...

    Authors: Kristen K. Bjorkman, Massimo Buvoli, Emily K. Pugach, Michael M. Polmear and Leslie A. Leinwand

    Citation: Skeletal Muscle 2019 9:31

    Content type: Research

    Published on:

  43. The mammalian target of rapamycin complex 2 (mTORC2), containing the essential protein rictor, regulates cellular metabolism and cytoskeletal organization by phosphorylating protein kinases, such as PKB/Akt, P...

    Authors: Nathalie Rion, Perrine Castets, Shuo Lin, Leonie Enderle, Judith R. Reinhard and Markus A. Rüegg

    Citation: Skeletal Muscle 2019 9:30

    Content type: Research

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